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Acetylcholine Receptor Channels Activated by a Single Agonist Molecule

The neuromuscular acetylcholine receptor (AChR) is an allosteric protein that alternatively adopts inactive versus active conformations (R↔R(∗)). The R(∗) shape has a higher agonist affinity and ionic conductance than R. To understand how agonists trigger this gating isomerization, we examined singl...

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Hlavní autoři: Jha, Archana, Auerbach, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862204/
https://ncbi.nlm.nih.gov/pubmed/20441747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.01.025
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