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Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats
BACKGROUND: The development of analgesic tolerance following chronic morphine administration can be a significant clinical problem. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition of gliosis prevents the development of analgesic toleran...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862024/ https://ncbi.nlm.nih.gov/pubmed/20398374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-22 |
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