Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats

BACKGROUND: The development of analgesic tolerance following chronic morphine administration can be a significant clinical problem. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition of gliosis prevents the development of analgesic toleran...

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Bibliographic Details
Main Authors: Mattioli, Theresa-Alexandra M, Milne, Brian, Cahill, Catherine M
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862024/
https://ncbi.nlm.nih.gov/pubmed/20398374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-22
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