A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

We describe a new form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea (ENU)-induced mutation called elektra. Homozygotes showed enhanced susceptibility to bacterial and viral infections, and diminished numbers of T cells and inflammatory monocytes that failed to proliferate upon...

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Detalhes bibliográficos
Main Authors: Berger, Michael, Krebs, Philippe, Crozat, Karine, Li, Xiaohong, Croker, Ben A., Siggs, Owen M., Popkin, Daniel, Du, Xin, Lawson, Brian R., Theofilopoulos, Argyrios N., Xia, Yu, Khovananth, Kevin, Moresco, Eva Marie Y., Satoh, Takashi, Takeuchi, Osamu, Akira, Shizuo, Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861894/
https://ncbi.nlm.nih.gov/pubmed/20190759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1847
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