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A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
We describe a new form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea (ENU)-induced mutation called elektra. Homozygotes showed enhanced susceptibility to bacterial and viral infections, and diminished numbers of T cells and inflammatory monocytes that failed to proliferate upon...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2861894/ https://ncbi.nlm.nih.gov/pubmed/20190759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1847 |
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