A Quantitative Model of Transcriptional Regulation Reveals the Influence of Binding Location on Expression

Understanding the mechanistic basis of transcriptional regulation has been a central focus of molecular biology since its inception. New high-throughput chromatin immunoprecipitation experiments have revealed that most regulatory proteins bind thousands of sites in mammalian genomes. However, the fu...

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Main Authors: MacIsaac, Kenzie D., Lo, Kinyui A., Gordon, William, Motola, Shmulik, Mazor, Tali, Fraenkel, Ernest
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861697/
https://ncbi.nlm.nih.gov/pubmed/20442865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000773
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