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αβ versus γδ lineage choice at the first TCR-controlled checkpoint

αβ and γδ T-cells develop in the thymus from a common precursor. Although lineages initially were defined by the type of TCR they express, it soon became clear that the TCR type per se does not play a deterministic role in the lineage decision, since in various transgenic and knockout models, as wel...

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Main Authors: Kreslavsky, Taras, Gleimer, Michael, von Boehmer, Harald
格式: Artigo
語言:Inglês
出版: 2010
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861550/
https://ncbi.nlm.nih.gov/pubmed/20074925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2009.12.006
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