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T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis

αβ and γδ T cell lineages develop in the thymus from a common precursor. It is unclear at which stage of development commitment to these lineages takes place and in which way T cell receptor signaling contributes to the process. Recently, it was demonstrated that strong TCR signals favor γδ lineage...

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Detalhes bibliográficos
Main Authors: Kreslavsky, Taras, Garbe, Annette I., Krueger, Andreas, von Boehmer, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373848/
https://ncbi.nlm.nih.gov/pubmed/18443226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072425
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