Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

The Claudin-like protein of 24 kDa (CLP24) is a hypoxia-regulated transmembrane protein of unknown function. We show here that clp24 knockdown in Danio rerio and Xenopus laevis results in defective lymphatic development. Targeted disruption of Clp24 in mice led to enlarged lymphatic vessels having a...

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Hlavní autoři: Saharinen, Pipsa, Helotera, Hanna, Miettinen, Juho, Norrmen, Camilla, D'Amico, Gabriela, Jeltsch, Michael, Langenberg, Tobias, Vandevelde, Wouter, Ny, Annelii, Dewerchin, Mieke, Carmeliet, Peter, Alitalo, Kari
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2010
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861186/
https://ncbi.nlm.nih.gov/pubmed/20439428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.565010
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