Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

The Claudin-like protein of 24 kDa (CLP24) is a hypoxia-regulated transmembrane protein of unknown function. We show here that clp24 knockdown in Danio rerio and Xenopus laevis results in defective lymphatic development. Targeted disruption of Clp24 in mice led to enlarged lymphatic vessels having a...

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Detalhes bibliográficos
Main Authors: Saharinen, Pipsa, Helotera, Hanna, Miettinen, Juho, Norrmen, Camilla, D'Amico, Gabriela, Jeltsch, Michael, Langenberg, Tobias, Vandevelde, Wouter, Ny, Annelii, Dewerchin, Mieke, Carmeliet, Peter, Alitalo, Kari
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861186/
https://ncbi.nlm.nih.gov/pubmed/20439428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.565010
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