Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

The Claudin-like protein of 24 kDa (CLP24) is a hypoxia-regulated transmembrane protein of unknown function. We show here that clp24 knockdown in Danio rerio and Xenopus laevis results in defective lymphatic development. Targeted disruption of Clp24 in mice led to enlarged lymphatic vessels having a...

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Bibliografski detalji
Glavni autori: Saharinen, Pipsa, Helotera, Hanna, Miettinen, Juho, Norrmen, Camilla, D'Amico, Gabriela, Jeltsch, Michael, Langenberg, Tobias, Vandevelde, Wouter, Ny, Annelii, Dewerchin, Mieke, Carmeliet, Peter, Alitalo, Kari
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2010
Teme:
Research Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861186/
https://ncbi.nlm.nih.gov/pubmed/20439428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.565010
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