Caveolin-1 Deficiency Dampens Toll-Like Receptor 4 Signaling through eNOS Activation

Caveolin-1 (Cav1), the scaffolding protein of caveolae, has been shown to play an important role in host defense and inflammation. However, the underlying molecular basis for these actions remains elusive. Here, using double mutant mice with genetic deletions of Cav1 and NOS3, we show that chronic e...

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Autores principales: Mirza, Muhammad K., Yuan, Jun, Gao, Xiao-Pei, Garrean, Sean, Brovkovych, Viktor, Malik, Asrar B., Tiruppathi, Chinnaswamy, Zhao, You-Yang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2010
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861099/
https://ncbi.nlm.nih.gov/pubmed/20304961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091088
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