Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

Pulmonary hypertension (PH) is an unremitting disease defined by a progressive increase in pulmonary vascular resistance leading to right-sided heart failure. Using mice with genetic deletions of caveolin 1 (Cav1) and eNOS (Nos3), we demonstrate here that chronic eNOS activation secondary to loss of...

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Hauptverfasser: Zhao, You-Yang, Zhao, Yidan D., Mirza, Muhammad K., Huang, Julia H., Potula, Hari-Hara S.K., Vogel, Steven M., Brovkovych, Viktor, Yuan, Jason X.-J., Wharton, John, Malik, Asrar B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2009
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701851/
https://ncbi.nlm.nih.gov/pubmed/19487814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33338
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