The Critical Role of AKT2 in Hepatic Steatosis Induced by PTEN Loss

Insulin signaling in the liver leads to accumulation of phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)). Deletion of the phosphatase Pten (phosphatase and tensin homologue deleted on chromosome 10) reduces PIP(3) levels and leads to fatty liver development. The purpose of this study was to inves...

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Hlavní autoři: He, Lina, Hou, Xiaogang, Kanel, Gary, Zeng, Ni, Galicia, Vivian, Wang, Ying, Yang, Jian, Wu, Hong, Birnbaum, Morris J., Stiles, Bangyan L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861095/
https://ncbi.nlm.nih.gov/pubmed/20348245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090931
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