A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

The human congenital syndromes ectrodactyly ectodermal dysplasia-cleft lip/palate syndrome, ankyloblepharon ectodermal dysplasia clefting, and split-hand/foot malformation are all characterized by ectodermal dysplasia, limb malformations, and cleft lip/palate. These phenotypic features are a result...

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Hlavní autoři: Moretti, Francesca, Marinari, Barbara, Lo Iacono, Nadia, Botti, Elisabetta, Giunta, Alessandro, Spallone, Giulia, Garaffo, Giulia, Vernersson-Lindahl, Emma, Merlo, Giorgio, Mills, Alea A., Ballarò, Costanza, Alemà, Stefano, Chimenti, Sergio, Guerrini, Luisa, Costanzo, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860936/
https://ncbi.nlm.nih.gov/pubmed/20424325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40267
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