The tumor suppressor activity of IKKα in stratified epithelia is exerted in part via the TGF-β antiproliferative pathway

The transforming growth factor type β-1 (TGF-β) signaling pathway is a major tumor suppressor during early carcinogenesis, and its growth-suppressive activity is commonly lost during early tumor progression. IκB kinase α (IKKα) also acts as a tumor suppressor in stratified epithelia, and its express...

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Hlavní autoři: Marinari, Barbara, Moretti, Francesca, Botti, Elisabetta, Giustizieri, Maria Laura, Descargues, Pascal, Giunta, Alessandro, Stolfi, Carmine, Ballaro, Costanza, Papoutsaki, Marina, Alemà, Stefano, Monteleone, Giovanni, Chimenti, Sergio, Karin, Michael, Costanzo, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579383/
https://ncbi.nlm.nih.gov/pubmed/18957551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809288105
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