Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

Type I IFN has been demonstrated to have major regulatory effects on the outcome of bacterial infections. To assess the effects of exogenously induced type I IFN on the outcome of Mycobacterium tuberculosis infection, we treated pathogen-exposed mice intranasally with polyinosinic-polycytidylic acid...

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Detalhes bibliográficos
Main Authors: Antonelli, Lis R.V., Gigliotti Rothfuchs, Antonio, Gonçalves, Ricardo, Roffê, Ester, Cheever, Allen W., Bafica, Andre, Salazar, Andres M., Feng, Carl G., Sher, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860920/
https://ncbi.nlm.nih.gov/pubmed/20389020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40817
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