NF-κB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes

AIMS: Inflammatory molecules and their transcription factor, nuclear factor kappa-B (NF-κB), are thought to play important roles in diabetes-induced cardiac dysfunction. Here, we investigated the effects of pyrrolidine dithiocarbamate (PDTC), a NF-κB inhibitor, in diabetic mice. METHODS AND RESULTS:...

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Autors principals: Mariappan, Nithya, Elks, Carrie M., Sriramula, Srinivas, Guggilam, Anuradha, Liu, Zhizhen, Borkhsenious, Olga, Francis, Joseph
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860708/
https://ncbi.nlm.nih.gov/pubmed/19729361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp305
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