Mass Spectral Characterization of Organophosphate-Labeled, Tyrosine-Containing Peptides: Characteristic Mass Fragments and A New Binding Motif for Organophosphates

We have identified organophosphorus agent (OP)-tyrosine adducts on 12 different proteins labeled with 6 different OP. Labeling was achieved by treating pure proteins with up to 40-fold molar excess of OP at pH 8–8.6. OP-treated proteins were digested with trypsin, and peptides were separated by HPLC...

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Hauptverfasser: Schopfer, Lawrence M., Grigoryan, Hasmik, Li, Bin, Nachon, Florian, Masson, Patrick, Lockridge, Oksana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860652/
https://ncbi.nlm.nih.gov/pubmed/19762289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2009.07.026
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