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Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2
Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators of this pathway is Dkk1, which antagonizes Wnt signalling through the formation of a ternary complex with the transmembrane receptors Krm1/2 and Lrp5/6, thereby blocking the induction of Wnt signalli...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860505/ https://ncbi.nlm.nih.gov/pubmed/20436912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010309 |
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