Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density

Kremen1 and Kremen2 (Krm1 and Krm2) are transmembrane coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/β-catenin signaling. The physiological relevance of Kremen proteins in mammals as Wnt modulators is unresolved. We generated and characterized Krm mutant mice and found that double mutants sh...

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Detalhes bibliográficos
Main Authors: Ellwanger, Kristina, Saito, Hiroaki, Clément-Lacroix, Philippe, Maltry, Nicole, Niedermeyer, Joachim, Lee, Woon Kyu, Baron, Roland, Rawadi, Georges, Westphal, Heiner, Niehrs, Christof
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493355/
https://ncbi.nlm.nih.gov/pubmed/18505822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00222-08
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