Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2

Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators of this pathway is Dkk1, which antagonizes Wnt signalling through the formation of a ternary complex with the transmembrane receptors Krm1/2 and Lrp5/6, thereby blocking the induction of Wnt signalli...

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Autors principals: Schulze, Jochen, Seitz, Sebastian, Saito, Hiroaki, Schneebauer, Michael, Marshall, Robert P., Baranowsky, Anke, Busse, Bjoern, Schilling, Arndt F., Friedrich, Felix W., Albers, Joachim, Spiro, Alexander S., Zustin, Jozef, Streichert, Thomas, Ellwanger, Kristina, Niehrs, Christof, Amling, Michael, Baron, Roland, Schinke, Thorsten
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860505/
https://ncbi.nlm.nih.gov/pubmed/20436912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010309
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