Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2

Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators of this pathway is Dkk1, which antagonizes Wnt signalling through the formation of a ternary complex with the transmembrane receptors Krm1/2 and Lrp5/6, thereby blocking the induction of Wnt signalli...

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Detalhes bibliográficos
Main Authors: Schulze, Jochen, Seitz, Sebastian, Saito, Hiroaki, Schneebauer, Michael, Marshall, Robert P., Baranowsky, Anke, Busse, Bjoern, Schilling, Arndt F., Friedrich, Felix W., Albers, Joachim, Spiro, Alexander S., Zustin, Jozef, Streichert, Thomas, Ellwanger, Kristina, Niehrs, Christof, Amling, Michael, Baron, Roland, Schinke, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860505/
https://ncbi.nlm.nih.gov/pubmed/20436912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010309
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