Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 Deoxy- Δ(12,14) - Prostaglandin J(2)

Arachidonic acid derived endogenous electrophile 15d-PGJ2 has gained much attention in recent years due to its potent anti-proliferative and anti-inflammatory actions mediated through thiol modification of cysteine residues in its target proteins. Here, we show that 15d-PGJ2 at 1µM concentration con...

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Main Authors: Mishra, Nandita, Kar, Rekha, Singha, Prajjal K., Venkatachalam, Manjeri A., McEwen, Donald G., Saikumar, Pothana
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859997/
https://ncbi.nlm.nih.gov/pubmed/20307494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.03.093
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