Large-scale Domain Dynamics and Adenosylcobalamin Reorientation Orchestrate Radical Catalysis in Ornithine 4,5-Aminomutase

d-Ornithine 4,5-aminomutase (OAM) from Clostridium sticklandii converts d-ornithine to 2,4-diaminopentanoic acid by way of radical propagation from an adenosylcobalamin (AdoCbl) to a pyridoxal 5′-phosphate (PLP) cofactor. We have solved OAM crystal structures in different catalytic states that toget...

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Detalhes bibliográficos
Main Authors: Wolthers, Kirsten R., Levy, Colin, Scrutton, Nigel S., Leys, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859556/
https://ncbi.nlm.nih.gov/pubmed/20106986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.068908
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