Glutamate 338 is an electrostatic facilitator of C–Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase

How cobalamin-dependent enzymes promote C–Co homolysis to initiate radical catalysis has been debated extensively. For the pyridoxal 5′-phosphate and cobalamin-dependent enzymes lysine 5,6-aminomutase and ornithine 4,5-aminomutase (OAM), large-scale re-orientation of the cobalamin-binding domain lin...

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Xehetasun bibliografikoak
Argitaratua izan da:FEBS J
Egile Nagusiak: Menon, Binuraj R K, Menon, Navya, Fisher, Karl, Rigby, Stephen E J, Leys, David, Scrutton, Nigel S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Blackwell Publishing Ltd 2015
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413051/
https://ncbi.nlm.nih.gov/pubmed/25627283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13215
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