Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic Lethality

Stress in the endoplasmic reticulum (ER) plays an important causal role in the pathogenesis of several chronic diseases such as Alzheimer, Parkinson, and diabetes mellitus. Insight into the genetic determinants responsible for ER homeostasis will greatly facilitate the development of therapeutic str...

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Detalhes bibliográficos
Main Authors: Francisco, Adam B., Singh, Rajni, Li, Shuai, Vani, Anish K., Yang, Liu, Munroe, Robert J., Diaferia, Giuseppe, Cardano, Marina, Biunno, Ida, Qi, Ling, Schimenti, John C., Long, Qiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859532/
https://ncbi.nlm.nih.gov/pubmed/20197277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085340
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