SEL1L Protein Critically Determines the Stability of the HRD1-SEL1L Endoplasmic Reticulum-associated Degradation (ERAD) Complex to Optimize the Degradation Kinetics of ERAD Substrates

The mammalian HRD1-SEL1L complex provides a scaffold for endoplasmic reticulum (ER)-associated degradation (ERAD), thereby connecting luminal substrates for ubiquitination at the cytoplasmic surface after their retrotranslocation through the endoplasmic reticulum membrane. In this study the stabilit...

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Bibliographic Details
Main Authors: Iida, Yasutaka, Fujimori, Tsutomu, Okawa, Katsuya, Nagata, Kazuhiro, Wada, Ikuo, Hosokawa, Nobuko
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089536/
https://ncbi.nlm.nih.gov/pubmed/21454652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.215871
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