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Direct Ubiquitination of β-Catenin by Siah-1 and Regulation by the Exchange Factor TBL1
β-Catenin is a key component of the Wnt signaling pathway that functions as a transcriptional co-activator of Wnt target genes. Upon UV-induced DNA damage, β-catenin is recruited for polyubiquitination and subsequent proteasomal degradation by a unique, p53-induced SCF-like complex (SCF(TBL1)), comp...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859511/ https://ncbi.nlm.nih.gov/pubmed/20181957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.049411 |
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