Direct Ubiquitination of β-Catenin by Siah-1 and Regulation by the Exchange Factor TBL1

β-Catenin is a key component of the Wnt signaling pathway that functions as a transcriptional co-activator of Wnt target genes. Upon UV-induced DNA damage, β-catenin is recruited for polyubiquitination and subsequent proteasomal degradation by a unique, p53-induced SCF-like complex (SCF(TBL1)), comp...

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Main Authors: Dimitrova, Yoana N., Li, Jiong, Lee, Young-Tae, Rios-Esteves, Jessica, Friedman, David B., Choi, Hee-Jung, Weis, William I., Wang, Cun-Yu, Chazin, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859511/
https://ncbi.nlm.nih.gov/pubmed/20181957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.049411
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