Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy

PURPOSE: Aberrant expression of inflammatory molecules, such as inducible nitric oxide synthase (iNOS), has been linked to cancer, suggesting that their inhibition is a rational therapeutic approach. While iNOS expression in melanoma and other cancers is associated with poor clinical prognosis, in v...

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Detalhes bibliográficos
Main Authors: Sikora, Andrew G., Gelbard, Alexander, Davies, Michael A., Sano, Daisuke, Ekmekcioglu, Suhendan, Kwon, John, Hailemichael, Yared, Jayaraman, Padmini, Myers, Jeffrey N., Grimm, Elizabeth A., Overwijk, Willem W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858983/
https://ncbi.nlm.nih.gov/pubmed/20215556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3123
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