Inducible nitric oxide synthase (iNOS) drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2

Melanoma is one of the cancers of fastest-rising incidence in the world. iNOS is overexpressed in melanoma and other cancers, and previous data suggest that iNOS and nitric oxide (NO) drive survival and proliferation of human melanoma cells. However, specific mechanisms through which this occurs are...

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Detalhes bibliográficos
Main Authors: Lopez-Rivera, Esther, Jayaraman, Padmini, Parikh, Falguni, Davies, Michael A., Ekmekcioglu, Suhendan, Izadmehr, Sudeh, Milton, Denái R., Chipuk, Jerry E., Grimm, Elizabeth A., Estrada, Yeriel, Aguirre-Ghiso, Julio, Sikora, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960077/
https://ncbi.nlm.nih.gov/pubmed/24398473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0588
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