iNOS Associates With Poor Survival in Melanoma: A Role for Nitric Oxide in the PI3K-AKT Pathway Stimulation and PTEN S-Nitrosylation

We previously showed that inducible nitric oxide synthase (iNOS) protein expression in melanoma tumor cells is associated with poor patient prognosis. Here, we analyzed the association between iNOS and the oncogenic PI3K-AKT pathway. TCGA data show that iNOS and phospho-Akt Ser473 expression were as...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Ding, Zhen, Ogata, Dai, Roszik, Jason, Qin, Yong, Kim, Sun-Hee, Tetzlaff, Michael T., Lazar, Alexander J., Davies, Michael A., Ekmekcioglu, Suhendan, Grimm, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907506/
https://ncbi.nlm.nih.gov/pubmed/33643925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.631766
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