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Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

Apoptosis in response to TRAIL or TNF requires the activation of initiator caspases, which then activate the effector caspases that dismantle cells and cause death. However, little is known about the dynamics and regulatory logic linking initiators and effectors. Using a combination of live-cell rep...

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Detalhes bibliográficos
Main Authors: Albeck, JG, Burke, JM, Aldridge, BB, Zhang, MS, Lauffenburger, DA, Sorger, PK
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858979/
https://ncbi.nlm.nih.gov/pubmed/18406323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.02.012
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