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Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death

When exposed to tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand (TRAIL), a closely related death ligand and investigational therapeutic, cells enter a protracted period of variable duration in which only upstream initiator caspases are active. A subsequent and sudden transition...

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Bibliografske podrobnosti
Main Authors: Albeck, John G, Burke, John M, Spencer, Sabrina L, Lauffenburger, Douglas A, Sorger, Peter K
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592357/
https://ncbi.nlm.nih.gov/pubmed/19053173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060299
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