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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein concentrations1–7. In mammalian cells, protein levels also vary8–10 and individual cells differ widely in responsiveness to uniform physiological stimuli11–15. In the case of apoptosis mediated by TRAIL (TN...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858974/ https://ncbi.nlm.nih.gov/pubmed/19363473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08012 |
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