Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Genetically encoded calcium indicators (GECIs) can be used to image activity in defined neuronal populations. However, current GECIs produce inferior signals compared to synthetic indicators and recording electrodes, precluding detection of low firing rates. We developed a single-wavelength GECI bas...

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Bibliografiska uppgifter
Huvudupphovsmän: Tian, Lin, Hires, S. Andrew, Mao, Tianyi, Huber, Daniel, Chiappe, M. Eugenia, Chalasani, Sreekanth H., Petreanu, Leopoldo, Akerboom, Jasper, McKinney, Sean A., Schreiter, Eric R., Bargmann, Cornelia I., Jayaraman, Vivek, Svoboda, Karel, Looger, Loren L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858873/
https://ncbi.nlm.nih.gov/pubmed/19898485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1398
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