Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design

The genetically encoded calcium indicator GCaMP2 shows promise for neural network activity imaging, but is currently limited by low signal-to-noise ratio. We describe x-ray crystal structures as well as solution biophysical and spectroscopic characterization of GCaMP2 in the calcium-free dark state,...

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Main Authors: Akerboom, Jasper, Rivera, Jonathan D. Vélez, Guilbe, María M. Rodríguez, Malavé, Elisa C. Alfaro, Hernandez, Hector H., Tian, Lin, Hires, S. Andrew, Marvin, Jonathan S., Looger, Loren L., Schreiter, Eric R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649101/
https://ncbi.nlm.nih.gov/pubmed/19098007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807657200
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