Impact of RNA Editing on Functions of the Serotonin 2C Receptor in vivo

Transcripts encoding 5-HT(2C) receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5-HT(2C-VGV), exhibits blunted G-protein coupling and reduced constitutive activity. The present studies examine the signal...

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Hlavní autoři: Olaghere da Silva, Uade B., Morabito, Michael V., Canal, Clinton E., Airey, David C., Emeson, Ronald B., Sanders-Bush, Elaine
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Research Foundation 2010
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858556/
https://ncbi.nlm.nih.gov/pubmed/20582266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/neuro.23.001.2010
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