Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi Syndrome

RNA transcripts encoding the 2C-subtype of serotonin (5HT(2C)) receptor undergo up to five adenosine-to-inosine editing events to encode twenty-four protein isoforms. To examine the effects of altered 5HT(2C) editing in vivo, we generated mutant mice solely expressing the fully-edited (VGV) isoform...

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Bibliographische Detailangaben
Hauptverfasser: Morabito, Michael V., Abbas, Atheir I., Hood, Jennifer L., Kesterson, Robert A., Jacobs, Michelle M., Kump, David S., Hachey, David L., Roth, Bryan L., Emeson, Ronald B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906772/
https://ncbi.nlm.nih.gov/pubmed/20394819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.04.004
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