The Human Breast Cancer Resistance Protein (BCRP/ABCG2) Shows Conformational Changes with Mitoxantrone

BCRP/ABCG2 mediates efflux of drugs and xenobiotics. BCRP was expressed in Pichia pastoris, purified to > 90% homogeneity, and subjected to two-dimensional (2-D) crystallization. The 2-D crystals showed a p12(1) symmetry and projection maps were determined at 5-Å resolution by electron cryomicros...

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Main Authors: Rosenberg, Mark F., Bikadi, Zsolt, Chan, Janice, Liu, Xiaoping, Ni, Zhanglin, Cai, Xiaokun, Ford, Robert C., Mao, Qingcheng
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858361/
https://ncbi.nlm.nih.gov/pubmed/20399185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.01.017
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