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Membrane Topology of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) Determined by Epitope Insertion and Immunofluorescence
The human breast cancer resistance protein (BCRP/ABCG2) mediates efflux of drugs and organic anions across the plasma membrane. Hydropathy analysis suggests that BCRP consists of a nucleotide-binding domain (residues ∼1-395) and a membrane-spanning domain (MSD) (residues ∼396-655); however, its exac...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2649121/ https://ncbi.nlm.nih.gov/pubmed/19063604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801644v |
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