Membrane Topology of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) Determined by Epitope Insertion and Immunofluorescence

The human breast cancer resistance protein (BCRP/ABCG2) mediates efflux of drugs and organic anions across the plasma membrane. Hydropathy analysis suggests that BCRP consists of a nucleotide-binding domain (residues ∼1-395) and a membrane-spanning domain (MSD) (residues ∼396-655); however, its exac...

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Hlavní autoři: Wang, Honggang, Lee, Eun-Woo, Cai, Xiaokun, Ni, Zhanglin, Zhou, Lin, Mao, Qingcheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649121/
https://ncbi.nlm.nih.gov/pubmed/19063604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801644v
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