Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport

The human breast cancer resistance protein (BCRP/ABCG2) mediates efflux of drugs and xenobiotics. In this study, we investigated the role of polar residues within or near the predicted transmembrane α-helices 1 and 6 of BCRP in drug transport. We substituted Asn(387), Gln(398), Asn(629), and Thr(642...

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Detalhes bibliográficos
Main Authors: Ni, Zhanglin, Bikadi, Zsolt, Cai, Xiaokun, Rosenberg, Mark F., Mao, Qingcheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980320/
https://ncbi.nlm.nih.gov/pubmed/20739628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00160.2010
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