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Identification of Proline Residues In or Near the Transmembrane Helices of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) Important for Transport Activity and Substrate Specificity()

The human breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance and mediates the active efflux of drugs and xenobiotics. BCRP contains one nucleotide-binding domain (NBD) followed by one membrane-spanning domain (MSD). We investigated whether prolines in or near the transmembran...

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Detalhes bibliográficos
Main Authors: Ni, Zhanglin, Bikadi, Zsolt, Shuster, Diana L., Zhao, Chunsheng, Rosenberg, Mark F., Mao, Qingcheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172388/
https://ncbi.nlm.nih.gov/pubmed/21854076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200573t
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