Differential Effects of Ethanol on Serum GABAergic 3α,5α/3α,5β Neuroactive Steroids in Mice, Rats, Cynomolgus Monkeys and Humans

BACKGROUND: Acute ethanol administration increases plasma and brain levels of progesterone and deoxycorticosterone-derived neuroactive steroids (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) and (3α,5α)-3,21-dihydroxypregnan-20-one (3α,5α-THDOC) in rats. However, little is known about ethanol effects o...

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Autores principales: Porcu, Patrizia, O’Buckley, Todd K., Alward, Sarah E., Song, Soomin C., Grant, Kathleen A., de Wit, Harriet, Morrow, A. Leslie
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858248/
https://ncbi.nlm.nih.gov/pubmed/20028362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2009.01123.x
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