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Covariate adjustment in randomized trials with binary outcomes: Targeted maximum likelihood estimation

Covariate adjustment using linear models for continuous outcomes in randomized trials has been shown to increase efficiency and power over the unadjusted method in estimating the marginal effect of treatment. However, for binary outcomes, investigators generally rely on the unadjusted estimate as th...

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Bibliografske podrobnosti
Main Authors: Moore, K. L., van der Laan, M. J.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857590/
https://ncbi.nlm.nih.gov/pubmed/18985634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3445
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