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Targeted maximum likelihood estimation in safety analysis

OBJECTIVES: To compare the performance of a targeted maximum likelihood estimator (TMLE) and a collaborative TMLE (CTMLE) to other estimators in a drug safety analysis, including a regression-based estimator, propensity score (PS)–based estimators, and an alternate doubly robust (DR) estimator in a...

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Main Authors: Lendle, Samuel D., Fireman, Bruce, van der Laan, Mark J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818128/
https://ncbi.nlm.nih.gov/pubmed/23849159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jclinepi.2013.02.017
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