Distinct Genetic Alterations in the Mitogen-Activated Protein Kinase Pathway Dictate Sensitivity of Thyroid Cancer Cells to Mitogen-Activated Protein Kinase Kinase 1/2 Inhibition

BACKGROUND: The mitogen-activated protein kinase (MAPK)/extracellular signal–regulated kinase (ERK) pathway plays an important role in papillary and anaplastic thyroid cancer (PTC and ATC) due to activating mutations in BRAF, RAS, or rearrangements in RET/PTC1. The objective of this study was to tho...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Schweppe, Rebecca E., Kerege, Anna A., Sharma, Vibha, Poczobutt, Joanna M., Gutierrez-Hartmann, Arthur, Grzywa, Rachel L., Haugen, Bryan R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Mary Ann Liebert, Inc. 2009
נושאים:
Original Studies, Reviews, and Scholarly Dialog
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857444/
https://ncbi.nlm.nih.gov/pubmed/19500021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2008.0362
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