FAK Expression, Not Kinase Activity, is a Key Mediator of Thyroid Tumorigenesis and Pro-tumorigenic Processes

There are limited therapy options for advanced thyroid cancer, including papillary and anaplastic thyroid cancer (PTC and ATC). Focal Adhesion Kinase (FAK) regulates cell signaling by functioning as a scaffold and kinase. Previously we demonstrated that FAK is overexpressed and activated in thyroid...

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Udgivet i:Mol Cancer Res
Main Authors: Kessler, Brittelle E., Sharma, Vibha, Zhou, Qiong, Jing, Xia, Pike, Laura A., Kerege, Anna A., Sams, Sharon B., Schweppe, Rebecca E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025360/
https://ncbi.nlm.nih.gov/pubmed/27259715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0007
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