Insulin-like Growth Factor-binding Protein-5-induced Laminin γ1 Transcription Requires Filamin A

Insulin-like growth factor-binding protein-5 (IGFBP-5) has IGF-1-independent intranuclear effects that are poorly defined. Treatment of cells with IGFBP-5 induces migration, prevents apoptosis, and leads to increased laminin subunit transcription. Similarly, filamin A (FLNa), an actin-binding protei...

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Bibliographic Details
Main Authors: Abrass, Christine K., Hansen, Kim M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857142/
https://ncbi.nlm.nih.gov/pubmed/20167606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061754
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