Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice

The insulin-like growth factors (IGFs) are essential for development; bioavailable IGF is tightly regulated by six related IGF-binding proteins (IGFBPs). Igfbp5 is the most conserved and is developmentally up-regulated in key lineages and pathologies; in vitro studies suggest that IGFBP-5 functions...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Salih, Dervis A. M., Tripathi, Gyanendra, Holding, Cathy, Szestak, Tadge A. M., Gonzalez, M. Ivelisse, Carter, Emma J., Cobb, Laura J., Eisemann, Joan E., Pell, Jennifer M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2004
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384738/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15010534/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400230101
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