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Analysis of a TIR-less Splice Variant of TRIF Reveals an Unexpected Mechanism of TLR3-mediated Signaling
Recognition of viral RNA by Toll-like receptor 3 (TLR3) triggers activation of the transcription factors NF-κB and IRF3 and induction of type I interferons. TRIF is a Toll-interleukin 1 receptor (TIR) domain-containing adapter protein critically involved in TLR3-mediated signaling. It has been shown...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857105/ https://ncbi.nlm.nih.gov/pubmed/20200155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072231 |
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